Dual role of USP30 in controlling basal pexophagy and mitophagy

USP30 is an integral protein of the outer mitochondrial membrane that counteracts PINK1 and Parkin‐dependent mitophagy following acute mitochondrial depolarisation. Here, we use two distinct mitophagy reporter systems to reveal tonic suppression by USP30, of a PINK1‐dependent component of basal mito...

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Bibliografiske detaljer
Udgivet i:EMBO Rep
Main Authors: Marcassa, Elena, Kallinos, Andreas, Jardine, Jane, Rusilowicz‐Jones, Emma V, Martinez, Aitor, Kuehl, Sandra, Islinger, Markus, Clague, Michael J, Urbé, Sylvie
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Scientific Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6030704/
https://ncbi.nlm.nih.gov/pubmed/29895712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201745595
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