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The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity
Ubiquitin-specific protease 15 (USP15) is a widely expressed deubiquitylase that has been implicated in diverse cellular processes in cancer. Here we identify topoisomerase II (TOP2A) as a novel protein that is regulated by USP15. TOP2A accumulates during G2 and functions to decatenate intertwined s...
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| Publié dans: | Oncogene |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5916918/ https://ncbi.nlm.nih.gov/pubmed/29429988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0092-0 |
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