The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity

Ubiquitin-specific protease 15 (USP15) is a widely expressed deubiquitylase that has been implicated in diverse cellular processes in cancer. Here we identify topoisomerase II (TOP2A) as a novel protein that is regulated by USP15. TOP2A accumulates during G2 and functions to decatenate intertwined s...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Fielding, Andrew B., Concannon, Matthew, Darling, Sarah, Rusilowicz-Jones, Emma V., Sacco, Joseph J., Prior, Ian A., Clague, Michael J., Urbé, Sylvie, Coulson, Judy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916918/
https://ncbi.nlm.nih.gov/pubmed/29429988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0092-0
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