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The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit
Reversible ubiquitylation of proteins contributes to their integrity, abundance and activity. The RE1-silencing transcription factor (REST) plays key physiological roles and is dysregulated in a spectrum of disease. It is rapidly turned over and is phosphorylated, polyubiquitylated and degraded en m...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3735711/ https://ncbi.nlm.nih.gov/pubmed/23708518 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.25035 |
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