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The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability
USP21 is a centrosome-associated deubiquitylase (DUB) that has been implicated in the formation of primary cilia – crucial organelles for the regulation of the Hedgehog (Hh) signaling pathway in vertebrates. Here, we identify KCTD6 – a cullin-3 E3-ligase substrate adapter that has been previously li...
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| Izdano u: | J Cell Sci |
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| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Company of Biologists Ltd
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5117204/ https://ncbi.nlm.nih.gov/pubmed/27621083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.188516 |
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