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The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability

USP21 is a centrosome-associated deubiquitylase (DUB) that has been implicated in the formation of primary cilia – crucial organelles for the regulation of the Hedgehog (Hh) signaling pathway in vertebrates. Here, we identify KCTD6 – a cullin-3 E3-ligase substrate adapter that has been previously li...

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Detalles Bibliográficos
Publicado en:J Cell Sci
Main Authors: Heride, Claire, Rigden, Daniel J., Bertsoulaki, Erithelgi, Cucchi, Danilo, De Smaele, Enrico, Clague, Michael J., Urbé, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5117204/
https://ncbi.nlm.nih.gov/pubmed/27621083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.188516
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