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The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells
The phosphatidylinositol-3-kinase (PI3K) pathway is commonly hyperactivated in cancer. One mechanism by which this occurs is by silencing of the phosphatase and tensin homolog (PTEN), a tumor suppressor and major antagonist of the pathway, through genetic, epigenetic or posttranscriptional mechanism...
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| Publicado no: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4351423/ https://ncbi.nlm.nih.gov/pubmed/24292675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.512 |
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