USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria. We present the characterisation of an N-cyano pyrrolidine compound, FT3967385, with high selectivity for USP30. We demonstrate that ubiquitylation of TOM20, a component of the outer mitochond...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Rusilowicz-Jones, Emma V, Jardine, Jane, Kallinos, Andreas, Pinto-Fernandez, Adan, Guenther, Franziska, Giurrandino, Mariacarmela, Barone, Francesco G, McCarron, Katy, Burke, Christopher J, Murad, Alejandro, Martinez, Aitor, Marcassa, Elena, Gersch, Malte, Buckmelter, Alexandre J, Kayser-Bricker, Katherine J, Lamoliatte, Frederic, Gajbhiye, Akshada, Davis, Simon, Scott, Hannah C, Murphy, Emma, England, Katherine, Mortiboys, Heather, Komander, David, Trost, Matthias, Kessler, Benedikt M, Ioannidis, Stephanos, Ahlijanian, Michael K, Urbé, Sylvie, Clague, Michael J
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362391/
https://ncbi.nlm.nih.gov/pubmed/32636217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000768
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