The JAK2 Inhibitor, AZD1480, Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

Persistent activation of Stat3 is oncogenic and is prevalent in a wide variety of human cancers. Chronic cytokine stimulation is associated with Stat3 activation in some tumors, implicating cytokine receptor-associated Jak family kinases. Using Jak2 inhibitors, we demonstrate a central role of Jaks...

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Hauptverfasser: Hedvat, Michael, Huszar, Dennis, Herrmann, Andreas, Gozgit, Joseph M., Schroeder, Anne, Sheehy, Adam, Buettner, Ralf, Proia, David, Kowolik, Claudia M., Xin, Hong, Armstrong, Brian, Bebernitz, Geraldine, Weng, Shaobu, Wang, Lin, Ye, Minwei, McEachern, Kristen, Chen, Huawei, Morosini, Deborah, Bell, Kirsten, Alimzhanov, Marat, Ioannidis, Stephanos, McCoon, Patricia, Cao, Zhu A., Yu, Hua, Jove, Richard, Zinda, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812011/
https://ncbi.nlm.nih.gov/pubmed/19962667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2009.10.015
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