Anti-angiogenic and anti-metastatic activity of JAK inhibitor AZD1480

STAT3 has important functions in both tumor cells and the tumor microenvironment to facilitate cancer progression. The STAT regulatory kinase JAK has been strongly implicated in promoting oncogenesis of various solid tumors, including through the use of JAK kinase inhibitors such as AZD1480. However...

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Detalhes bibliográficos
Main Authors: Xin, Hong, Herrmann, Andreas, Reckamp, Karen, Zhang, Wang, Pal, Sumanta, Hedvat, Michael, Zhang, Chunyan, Liang, Wei, Scuto, Anna, Weng, Shaobu, Morosini, Deborah, Cao, Zhu A., Zinda, Michael, Figlin, Robert, Huszar, Dennis, Jove, Richard, Yu, Hua
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206173/
https://ncbi.nlm.nih.gov/pubmed/21920898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1217
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