Anti-angiogenic and anti-metastatic activity of JAK inhibitor AZD1480

STAT3 has important functions in both tumor cells and the tumor microenvironment to facilitate cancer progression. The STAT regulatory kinase JAK has been strongly implicated in promoting oncogenesis of various solid tumors, including through the use of JAK kinase inhibitors such as AZD1480. However...

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Autores principales: Xin, Hong, Herrmann, Andreas, Reckamp, Karen, Zhang, Wang, Pal, Sumanta, Hedvat, Michael, Zhang, Chunyan, Liang, Wei, Scuto, Anna, Weng, Shaobu, Morosini, Deborah, Cao, Zhu A., Zinda, Michael, Figlin, Robert, Huszar, Dennis, Jove, Richard, Yu, Hua
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206173/
https://ncbi.nlm.nih.gov/pubmed/21920898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1217
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