PHARMACOLOGICAL SUPPRESSION OF JAK1/2 BY JAK1/2 INHIBITOR AZD1480 POTENTLY INHIBITS IL-6-INDUCED EXPERIMENTAL PROSTATE CANCER METASTASES FORMATION

Metastatic prostate cancer (PC) is lethal and lacks effective strategies for prevention or treatment, requiring novel therapeutic approaches. Interleukin-6 (IL-6) is a cytokine which has been linked with PC pathogenesis by multiple studies. However, the direct functional role(s) of IL-6 in PC growth...

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Detalhes bibliográficos
Main Authors: Gu, Lei, Talati, Pooja, Vogiatzi, Paraskevi, Romero-Weaver, Ana L., Abdulghani, Junaid, Liao, Zhiyong, Leiby, Benjamin, Hoang, David T., Mirtti, Tuomas, Alanen, Kalle, Zinda, Michael, Huszar, Dennis, Nevalainen, Marja T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013199/
https://ncbi.nlm.nih.gov/pubmed/24577942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0605
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