Activating Mutation (V617F) in the Tyrosine Kinase JAK2 is Absent in Locally-Confined or Castration-Resistant Prostate Cancer

Background: Transcription factor Stat5a/b is highly critical for the viability of human prostate cancer cells in vitro and for prostate tumor growth in vivo. Stat5 is constitutively active in clinical prostate cancers but not in the normal human prostate epithelium. Moreover, Stat5a/b activation in...

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Detalhes bibliográficos
Publicado no:Anal Cell Pathol (Amst)
Main Authors: Gu, Lei, Zhu, Xian-Hua, Visakorpi, Tapio, Alanen, Kalle, Mirtti, Tuomas, Edmonston, Tina Bocker, Nevalainen, Marja T.
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605774/
https://ncbi.nlm.nih.gov/pubmed/20966544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/ACP-CLO-2010-0534
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