HSF1: Essential for Myeloma Cell Survival and A Promising Therapeutic Target

PURPOSE: Myeloma is a plasma cell malignancy characterized by the overproduction of immunoglobulin and is therefore susceptible to therapies targeting protein homeostasis. We hypothesized that heat shock factor 1 (HSF1) was an attractive therapeutic target for myeloma due to its direct regulation of...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Fok, Jacqueline H L, Hedayat, Somaieh, Zhang, Lei, Aronson, Lauren I., Mirabella, Fabio, Pawlyn, Charlotte, Bright, Michael D., Wardell, Christopher P., Keats, Jonathan J, De Billy, Emmanuel, Rye, Carl S., Chessum, Nicola E. A., Jones, Keith, Morgan, Gareth J., Eccles, Suzanne A., Workman, Paul, Davies, Faith E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420136/
https://ncbi.nlm.nih.gov/pubmed/29391353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1594
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