HSF1: Essential for Myeloma Cell Survival and A Promising Therapeutic Target

PURPOSE: Myeloma is a plasma cell malignancy characterized by the overproduction of immunoglobulin and is therefore susceptible to therapies targeting protein homeostasis. We hypothesized that heat shock factor 1 (HSF1) was an attractive therapeutic target for myeloma due to its direct regulation of...

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Publicado en:Clin Cancer Res
Main Authors: Fok, Jacqueline H L, Hedayat, Somaieh, Zhang, Lei, Aronson, Lauren I., Mirabella, Fabio, Pawlyn, Charlotte, Bright, Michael D., Wardell, Christopher P., Keats, Jonathan J, De Billy, Emmanuel, Rye, Carl S., Chessum, Nicola E. A., Jones, Keith, Morgan, Gareth J., Eccles, Suzanne A., Workman, Paul, Davies, Faith E.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420136/
https://ncbi.nlm.nih.gov/pubmed/29391353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1594
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