A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2

Intracellular antibodies are tools that can be used directly for target validation by interfering with properties like protein-protein interactions. An alternative use of intracellular antibodies in drug discovery is developing small-molecule surrogates using antibody-derived (Abd) technology. We pr...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Bery, Nicolas, Bataille, Carole J.R., Russell, Angela, Hayes, Angela, Raynaud, Florence, Milhas, Sabine, Anand, Sneha, Tulmin, Hanna, Miller, Ami, Rabbitts, Terence H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034850/
https://ncbi.nlm.nih.gov/pubmed/33837087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg1950
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