A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2

Intracellular antibodies are tools that can be used directly for target validation by interfering with properties like protein-protein interactions. An alternative use of intracellular antibodies in drug discovery is developing small-molecule surrogates using antibody-derived (Abd) technology. We pr...

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Publicat a:Sci Adv
Autors principals: Bery, Nicolas, Bataille, Carole J.R., Russell, Angela, Hayes, Angela, Raynaud, Florence, Milhas, Sabine, Anand, Sneha, Tulmin, Hanna, Miller, Ami, Rabbitts, Terence H.
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8034850/
https://ncbi.nlm.nih.gov/pubmed/33837087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg1950
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