Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

Targeting specific protein–protein interactions (PPIs) is an attractive concept for drug development, but hard to implement since intracellular antibodies do not penetrate cells and most small-molecule drugs are considered unsuitable for PPI inhibition. A potential solution to these problems is to s...

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Publicat a:Nat Commun
Autors principals: Quevedo, Camilo E., Cruz-Migoni, Abimael, Bery, Nicolas, Miller, Ami, Tanaka, Tomoyuki, Petch, Donna, Bataille, Carole J. R., Lee, Lydia Y. W., Fallon, Phillip S., Tulmin, Hanna, Ehebauer, Matthias T., Fernandez-Fuentes, Narcis, Russell, Angela J., Carr, Stephen B., Phillips, Simon E. V., Rabbitts, Terence H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085350/
https://ncbi.nlm.nih.gov/pubmed/30093669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05707-2
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