BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions

The RAS family of proteins is amongst the most highly mutated in human cancers and has so far eluded drug therapy. Currently, much effort is being made to discover mutant RAS inhibitors and in vitro screening for RAS-binding drugs must be followed by cell-based assays. Here, we have developed a robu...

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Veröffentlicht in:eLife
Hauptverfasser: Bery, Nicolas, Cruz-Migoni, Abimael, Bataille, Carole JR, Quevedo, Camilo E, Tulmin, Hanna, Miller, Ami, Russell, Angela, Phillips, Simon EV, Carr, Stephen B, Rabbitts, Terence H
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2018
Schlagworte:
Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039175/
https://ncbi.nlm.nih.gov/pubmed/29989546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.37122
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