Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment

Targeting specific protein–protein interactions (PPIs) is an attractive concept for drug development, but hard to implement since intracellular antibodies do not penetrate cells and most small-molecule drugs are considered unsuitable for PPI inhibition. A potential solution to these problems is to s...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Quevedo, Camilo E., Cruz-Migoni, Abimael, Bery, Nicolas, Miller, Ami, Tanaka, Tomoyuki, Petch, Donna, Bataille, Carole J. R., Lee, Lydia Y. W., Fallon, Phillip S., Tulmin, Hanna, Ehebauer, Matthias T., Fernandez-Fuentes, Narcis, Russell, Angela J., Carr, Stephen B., Phillips, Simon E. V., Rabbitts, Terence H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085350/
https://ncbi.nlm.nih.gov/pubmed/30093669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05707-2
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