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A cell-based screening method using an intracellular antibody for discovering small molecules targeting the translocation protein LMO2
Intracellular antibodies are tools that can be used directly for target validation by interfering with properties like protein-protein interactions. An alternative use of intracellular antibodies in drug discovery is developing small-molecule surrogates using antibody-derived (Abd) technology. We pr...
Enregistré dans:
| Publié dans: | Sci Adv |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Association for the Advancement of Science
2021
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8034850/ https://ncbi.nlm.nih.gov/pubmed/33837087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abg1950 |
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