Competitive SPR using an intracellular anti-LMO2 antibody identifies novel LMO2-interacting compounds

The use of intracellular antibodies as templates to derive surrogate compounds is an important objective because intracellular antibodies can be employed initially for target validation in pre-clinical assays and subsequently employed in compound library screens. LMO2 is a T cell oncogenic protein a...

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Detalhes bibliográficos
Publicado no:J Immunol Methods
Main Authors: Canning, Peter, Bataille, Carole, Bery, Nicolas, Milhas, Sabine, Hayes, Angela, Raynaud, Florence, Miller, Ami, Rabbitts, Terry
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Technical Note
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8208243/
https://ncbi.nlm.nih.gov/pubmed/33794223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2021.113051
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