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A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
Tumour-associated KRAS mutations are the most prevalent in the three RAS-family isoforms and involve many different amino-acids. Therefore, molecules able to interfere with mutant KRAS protein are potentially important for wide-ranging tumour therapy. We describe the engineering of two RAS degraders...
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| Udgivet i: | Nat Commun |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7319959/ https://ncbi.nlm.nih.gov/pubmed/32591521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17022-w |
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