Structure Enabled Design of BAZ2-ICR, A Chemical Probe Targeting the Bromodomains of BAZ2A and BAZ2B

[Image: see text] The bromodomain containing proteins BAZ2A/B play essential roles in chromatin remodeling and regulation of noncoding RNAs. We present the structure based discovery of a potent, selective, and cell active inhibitor 13 (BAZ2-ICR) of the BAZ2A/B bromodomains through rapid optimization...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Drouin, Ludovic, McGrath, Sally, Vidler, Lewis R., Chaikuad, Apirat, Monteiro, Octovia, Tallant, Cynthia, Philpott, Martin, Rogers, Catherine, Fedorov, Oleg, Liu, Manjuan, Akhtar, Wasim, Hayes, Angela, Raynaud, Florence, Müller, Susanne, Knapp, Stefan, Hoelder, Swen
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4441536/
https://ncbi.nlm.nih.gov/pubmed/25719566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501963e
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados