Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening

[Image: see text] The discovery of novel bromodomain inhibitors by fragment screening is complicated by the presence of dimethyl sulfoxide (DMSO), an acetyl-lysine mimetic, that can compromise the detection of low affinity fragments. We demonstrate surface plasmon resonance as a primary fragment scr...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Navratilova, Iva, Aristotelous, Tonia, Picaud, Sarah, Chaikuad, Apirat, Knapp, Stefan, Filappakopoulos, Panagis, Hopkins, Andrew L.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2016
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5150684/
https://ncbi.nlm.nih.gov/pubmed/27994766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00154
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