Fragment Screening by Surface Plasmon Resonance

Por Navratilova, Iva, Hopkins, Andrew L.
Publicado em 2010

Screening for GPCR Ligands Using Surface Plasmon Resonance

Por Navratilova, Iva, Besnard, Jérémy, Hopkins, Andrew L.
Publicado em 2011

Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening

Por Navratilova, Iva, Aristotelous, Tonia, Picaud, Sarah, Chaikuad, Apirat, Knapp, Stefan, Filappakopoulos, Panagis, Hopkins, Andrew L.
Publicado no ACS Med Chem Lett (2016)

Substrate and product analogues as human O-GlcNAc transferase inhibitors

Por Dorfmueller, Helge C., Borodkin, Vladimir S., Blair, David E., Pathak, Shalini, Navratilova, Iva, van Aalten, Daan M. F.
Publicado em 2010

O-GlcNAcase fragment discovery with fluorescence polarimetry

Por Borodkin, Vladimir S., Rafie, Karim, Selvan, Nithya, Aristotelous, Tonia, Navratilova, Iva, Ferenbach, Andrew T., van Aalten, Daan M. F.
Publicado no ACS Chem Biol (2018)

Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

Por Rao, Francesco V., Schüttelkopf, Alexander W., Dorfmueller, Helge C., Ferenbach, Andrew T., Navratilova, Iva, van Aalten, Daan M. F.
Publicado em 2013

Mechanism of ubiquitylation by dimeric RING ligase RNF4

Por Plechanovová, Anna, Jaffray, Ellis G., McMahon, Stephen A., Johnson, Kenneth A., Navrátilová, Iva, Naismith, James H., Hay, Ronald T.
Publicado em 2011

A mutant O-GlcNAcase as a probe to reveal global dynamics of the Drosophila O-GlcNAc developmental proteome

Por Mariappa, Daniel, Selvan, Nithya, Borodkin, Vladimir, Alonso, Jana, Ferenbach, Andrew T., Shepherd, Claire, Navratilova, Iva Hopkins, vanAalten, Daan M. F.
Publicado no Biochem J (2015)

Mining Public Domain Data to Develop Selective DYRK1A Inhibitors

Por Henderson, Scott H., Sorrell, Fiona, Bennett, James, Hanley, Marcus T., Robinson, Sean, Hopkins Navratilova, Iva, Elkins, Jonathan M., Ward, Simon E.
Publicado no ACS Med Chem Lett (2020)

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

Por Zeqiraj, Elton, Filippi, Beatrice Maria, Goldie, Simon, Navratilova, Iva, Boudeau, Jérôme, Deak, Maria, Alessi, Dario R., van Aalten, Daan M. F.
Publicado em 2009

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Por Filippi, Beatrice M, de los Heros, Paola, Mehellou, Youcef, Navratilova, Iva, Gourlay, Robert, Deak, Maria, Plater, Lorna, Toth, Rachel, Zeqiraj, Elton, Alessi, Dario R
Publicado em 2011

A mutant O-GlcNAcase enriches Drosophila developmental regulators

Por Selvan, Nithya, Williamson, Ritchie, Mariappa, Daniel, Campbell, David G., Gourlay, Robert, Ferenbach, Andrew T., Aristotelous, Tonia, Hopkins-Navratilova, Iva, Trost, Matthias, van Aalten, Daan M. F.
Publicado no Nat Chem Biol (2017)

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

Por Schimpl, Marianne, Zheng, Xiaowei, Borodkin, Vladimir S., Blair, David E., Ferenbach, Andrew T., Schüttelkopf, Alexander W., Navratilova, Iva, Aristotelous, Tonia, Albarbarawi, Osama, Robinson, David A., Macnaughtan, Megan A., van Aalten, Daan M.F.
Publicado em 2012

A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei

Por Urbaniak, Michael D., Collie, Iain T., Fang, Wenxia, Aristotelous, Tonia, Eskilsson, Susanne, Raimi, Olawale G., Harrison, Justin, Navratilova, Iva Hopkins, Frearson, Julie A., van Aalten, Daan M. F., Ferguson, Michael A. J.
Publicado em 2013

GacA is essential for Group A S treptococcus and defines a new class of monomeric dTDP‐4‐dehydrorhamnose reductases (RmlD)

Por van der Beek, Samantha L., Le Breton, Yoann, Ferenbach, Andrew T., Chapman, Robert N., van Aalten, Daan M. F., Navratilova, Iva, Boons, Geert‐Jan, McIver, Kevin S., van Sorge, Nina M., Dorfmueller, Helge C.
Publicado no Mol Microbiol (2015)

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

Por Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K., Gawron, Sylwia, Sassano, Maria F., Kahsai, Alem W., Wingler, Laura M., Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnard, Jérémy, Read, Kevin D., Roth, Bryan L., Gilbert, Ian H., Hopkins, Andrew L., Lefkowitz, Robert J., Navratilova, Iva
Publicado em 2013

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

Por Mousnier, Aurélie, Bell, Andrew S., Swieboda, Dawid P., Morales-Sanfrutos, Julia, Pérez-Dorado, Inmaculada, Brannigan, James A., Newman, Joseph, Ritzefeld, Markus, Hutton, Jennie A., Guedán, Anabel, Asfor, Amin A., Robinson, Sean W., Hopkins-Navratilova, Iva, Wilkinson, Anthony J., Johnston, Sebastian L., Leatherbarrow, Robin J., Tuthill, Tobias J., Solari, Roberto, Tate, Edward W.
Publicado no Nat Chem (2018)