MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Mouse protein-25 (MO25) isoforms bind to the STRAD pseudokinase and stabilise it in a conformation that can activate the LKB1 tumour suppressor kinase. We demonstrate that by binding to several STE20 family kinases, MO25 has roles beyond controlling LKB1. These new MO25 targets are SPAK/OSR1 kinases...

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Detalhes bibliográficos
Main Authors: Filippi, Beatrice M, de los Heros, Paola, Mehellou, Youcef, Navratilova, Iva, Gourlay, Robert, Deak, Maria, Plater, Lorna, Toth, Rachel, Zeqiraj, Elton, Alessi, Dario R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101989/
https://ncbi.nlm.nih.gov/pubmed/21423148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.78
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