ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

Pseudokinases lack essential residues for kinase activity, yet are emerging as important regulators of signal transduction networks. The pseudokinase STRAD activates the LKB1 tumour suppressor by forming a heterotrimeric complex with LKB1 and the scaffolding protein MO25. Here, we describe the struc...

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Autors principals: Zeqiraj, Elton, Filippi, Beatrice Maria, Goldie, Simon, Navratilova, Iva, Boudeau, Jérôme, Deak, Maria, Alessi, Dario R., van Aalten, Daan M. F.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2686265/
https://ncbi.nlm.nih.gov/pubmed/19513107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000126
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