MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Mutations in the LKB1 protein kinase result in the inherited Peutz Jeghers cancer syndrome. LKB1 has been implicated in regulating cell proliferation and polarity although little is known about how this enzyme is regulated. We recently showed that LKB1 is activated through its interaction with STRAD...

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Main Authors: Boudeau, Jérôme, Baas, Annette F., Deak, Maria, Morrice, Nick A., Kieloch, Agnieszka, Schutkowski, Mike, Prescott, Alan R., Clevers, Hans C., Alessi, Dario R.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC204473/
https://ncbi.nlm.nih.gov/pubmed/14517248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg490
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