Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

BACKGROUND: The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation. Activation requires phosphorylation of Thr172 of AMPK within the activation loop by upstream kinases (AMPKKs) that hav...

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Detalhes bibliográficos
Main Authors: Hawley, Simon A, Boudeau, Jérôme, Reid, Jennifer L, Mustard, Kirsty J, Udd, Lina, Mäkelä, Tomi P, Alessi, Dario R, Hardie, D Grahame
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC333410/
https://ncbi.nlm.nih.gov/pubmed/14511394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-4924-2-28
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