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Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
The LKB1 gene encodes a serine/threonine kinase mutated in Peutz–Jeghers cancer syndrome. Despite several proposed models for LKB1 function in development and in tumour suppression, the detailed molecular action of LKB1 remains undefined. Here, we report the identification and characterization of an...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2003
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC162144/ https://ncbi.nlm.nih.gov/pubmed/12805220 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg292 |
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