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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation
The LKB1 tumor suppressor is a protein kinase that controls activity of adenine monophosphate-activated protein kinase (AMPK). LKB1 activity is regulated by the pseudokinase STRADα and the scaffolding protein MO25α, through an unknown, phosphorylation-independent, mechanism. We describe the structur...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3518268/ https://ncbi.nlm.nih.gov/pubmed/19892943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1178377 |
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