SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Mutations in the WNK [with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has been on WNK1, which is activated in response to osmotic stress by phosphorylation of its T-loop residue (Ser(382)). WNK isoforms phosphorylate...

Full description

Saved in:
Bibliographic Details
Main Authors: Thastrup, Jacob O., Rafiqi, Fatema H., Vitari, Alberto C., Pozo-Guisado, Eulalia, Deak, Maria, Mehellou, Youcef, Alessi, Dario R.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242505/
https://ncbi.nlm.nih.gov/pubmed/22032326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111879
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items