SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Mutations in the WNK [with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has been on WNK1, which is activated in response to osmotic stress by phosphorylation of its T-loop residue (Ser(382)). WNK isoforms phosphorylate...

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Main Authors: Thastrup, Jacob O., Rafiqi, Fatema H., Vitari, Alberto C., Pozo-Guisado, Eulalia, Deak, Maria, Mehellou, Youcef, Alessi, Dario R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Portland Press Ltd. 2011
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242505/
https://ncbi.nlm.nih.gov/pubmed/22032326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111879
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