SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

Mutations in the WNK [with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has been on WNK1, which is activated in response to osmotic stress by phosphorylation of its T-loop residue (Ser(382)). WNK isoforms phosphorylate...

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Autors principals: Thastrup, Jacob O., Rafiqi, Fatema H., Vitari, Alberto C., Pozo-Guisado, Eulalia, Deak, Maria, Mehellou, Youcef, Alessi, Dario R.
Format: Artigo
Idioma:Inglês
Publicat: Portland Press Ltd. 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242505/
https://ncbi.nlm.nih.gov/pubmed/22032326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111879
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