Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

The SPAK (STE20/SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase-1) kinases interact and phosphorylate NKCC1 (Na(+)–K(+)–2Cl(−) co-transporter-1), leading to its activation. Recent studies indicated that SPAK and OSR1 are phosphorylated and activated by the WNK1...

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Detalhes bibliográficos
Main Authors: Vitari, Alberto C., Thastrup, Jacob, Rafiqi, Fatema H., Deak, Maria, Morrice, Nick A., Karlsson, Håkan K. R., Alessi, Dario R.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479760/
https://ncbi.nlm.nih.gov/pubmed/16669787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060220
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