Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1

The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (broad kinase inhibitor) and N-ethylmalemide (...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Zhang, Jinwei, Cordshagen, Antje, Medina, Igor, Nothwang, Hans Gerd, Wisniewski, Jacek R., Winklhofer, Michael, Hartmann, Anna-Maria
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228128/
https://ncbi.nlm.nih.gov/pubmed/32413057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0232967
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