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Phosphoregulation of the intracellular termini of K(+)-Cl(−) cotransporter 2 (KCC2) enables flexible control of its activity
The pivotal role of K(+)-Cl(−) cotransporter 2 (KCC2) in inhibitory neurotransmission and severe human diseases fosters interest in understanding posttranslational regulatory mechanisms such as (de)phosphorylation. Here, the regulatory role of the five bona fide phosphosites Ser(31), Thr(34), Ser(93...
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| Udgivet i: | J Biol Chem |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6222103/ https://ncbi.nlm.nih.gov/pubmed/30201606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004349 |
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