Structural changes in the extracellular loop 2 of the murine KCC2 potassium chloride cotransporter modulate ion transport

K(+)–Cl(−) cotransporters (KCCs) play important roles in physiological processes such as inhibitory neurotransmission and cell-volume regulation. KCCs exhibit significant variations in K(+) affinities, yet recent atomic structures demonstrated that K(+)- and Cl(−)-binding sites are highly conserved,...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Hartmann, Anna-Maria, Fu, Lifei, Ziegler, Christine, Winklhofer, Michael, Nothwang, Hans Gerd
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8191313/
https://ncbi.nlm.nih.gov/pubmed/34019872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100793
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