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A Novel Regulatory Locus of Phosphorylation in the C Terminus of the Potassium Chloride Cotransporter KCC2 That Interferes with N-Ethylmaleimide or Staurosporine-mediated Activation

The neuron-specific cation chloride cotransporter KCC2 plays a crucial role in hyperpolarizing synaptic inhibition. Transporter dysfunction is associated with various neurological disorders, raising interest in regulatory mechanisms. Phosphorylation has been identified as a key regulatory process. H...

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מידע ביבליוגרפי
Main Authors: Weber, Maren, Hartmann, Anna-Maria, Beyer, Timo, Ripperger, Anne, Nothwang, Hans Gerd
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4081912/
https://ncbi.nlm.nih.gov/pubmed/24849604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.567834
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