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Phosphoregulation of the intracellular termini of K(+)-Cl(−) cotransporter 2 (KCC2) enables flexible control of its activity

The pivotal role of K(+)-Cl(−) cotransporter 2 (KCC2) in inhibitory neurotransmission and severe human diseases fosters interest in understanding posttranslational regulatory mechanisms such as (de)phosphorylation. Here, the regulatory role of the five bona fide phosphosites Ser(31), Thr(34), Ser(93...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Cordshagen, Antje, Busch, Wiebke, Winklhofer, Michael, Nothwang, Hans Gerd, Hartmann, Anna-Maria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222103/
https://ncbi.nlm.nih.gov/pubmed/30201606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004349
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