The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

Mutations in the human genes encoding WNK1 [with no K (lysine) protein kinase-1] and the related protein kinase WNK4 are the cause of Gordon's hypertension syndrome. Little is known about the molecular mechanism by which WNK isoforms regulate cellular processes. We immunoprecipitated WNK1 from...

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Detalhes bibliográficos
Main Authors: Vitari, Alberto C., Deak, Maria, Morrice, Nick A., Alessi, Dario R.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Accelerated Publication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1237134/
https://ncbi.nlm.nih.gov/pubmed/16083423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051180
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