The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

Mutations in the human genes encoding WNK1 [with no K (lysine) protein kinase-1] and the related protein kinase WNK4 are the cause of Gordon's hypertension syndrome. Little is known about the molecular mechanism by which WNK isoforms regulate cellular processes. We immunoprecipitated WNK1 from...

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Bibliographische Detailangaben
Hauptverfasser: Vitari, Alberto C., Deak, Maria, Morrice, Nick A., Alessi, Dario R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2005
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Accelerated Publication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1237134/
https://ncbi.nlm.nih.gov/pubmed/16083423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051180
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