Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

Mutations within the WNK1 (with-no-K[Lys] kinase-1) gene cause Gordon's hypertension syndrome. Little is known about how WNK1 is regulated. We demonstrate that WNK1 is rapidly activated and phosphorylated at multiple residues after exposure of cells to hyperosmotic conditions and that activatio...

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Hauptverfasser: Zagórska, Anna, Pozo-Guisado, Eulalia, Boudeau, Jérôme, Vitari, Alberto C., Rafiqi, Fatema H., Thastrup, Jacob, Deak, Maria, Campbell, David G., Morrice, Nick A., Prescott, Alan R., Alessi, Dario R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2007
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063630/
https://ncbi.nlm.nih.gov/pubmed/17190791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200605093
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