Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening

per Navratilova, Iva, Aristotelous, Tonia, Picaud, Sarah, Chaikuad, Apirat, Knapp, Stefan, Filappakopoulos, Panagis, Hopkins, Andrew L.
Publicat a ACS Med Chem Lett (2016)

O-GlcNAcase fragment discovery with fluorescence polarimetry

per Borodkin, Vladimir S., Rafie, Karim, Selvan, Nithya, Aristotelous, Tonia, Navratilova, Iva, Ferenbach, Andrew T., van Aalten, Daan M. F.
Publicat a ACS Chem Biol (2018)

A mutant O-GlcNAcase enriches Drosophila developmental regulators

per Selvan, Nithya, Williamson, Ritchie, Mariappa, Daniel, Campbell, David G., Gourlay, Robert, Ferenbach, Andrew T., Aristotelous, Tonia, Hopkins-Navratilova, Iva, Trost, Matthias, van Aalten, Daan M. F.
Publicat a Nat Chem Biol (2017)

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

per Schimpl, Marianne, Zheng, Xiaowei, Borodkin, Vladimir S., Blair, David E., Ferenbach, Andrew T., Schüttelkopf, Alexander W., Navratilova, Iva, Aristotelous, Tonia, Albarbarawi, Osama, Robinson, David A., Macnaughtan, Megan A., van Aalten, Daan M.F.
Publicat 2012

A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei

per Urbaniak, Michael D., Collie, Iain T., Fang, Wenxia, Aristotelous, Tonia, Eskilsson, Susanne, Raimi, Olawale G., Harrison, Justin, Navratilova, Iva Hopkins, Frearson, Julie A., van Aalten, Daan M. F., Ferguson, Michael A. J.
Publicat 2013

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

per Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K., Gawron, Sylwia, Sassano, Maria F., Kahsai, Alem W., Wingler, Laura M., Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnard, Jérémy, Read, Kevin D., Roth, Bryan L., Gilbert, Ian H., Hopkins, Andrew L., Lefkowitz, Robert J., Navratilova, Iva
Publicat 2013