A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei

[Image: see text] Uridine diphosphate N-acetylglucosamine pyrophosphorylase (UAP) catalyzes the final reaction in the biosynthesis of UDP-GlcNAc, an essential metabolite in many organisms including Trypanosoma brucei, the etiological agent of Human African Trypanosomiasis. High-throughput screening...

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Main Authors: Urbaniak, Michael D., Collie, Iain T., Fang, Wenxia, Aristotelous, Tonia, Eskilsson, Susanne, Raimi, Olawale G., Harrison, Justin, Navratilova, Iva Hopkins, Frearson, Julie A., van Aalten, Daan M. F., Ferguson, Michael A. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780468/
https://ncbi.nlm.nih.gov/pubmed/23834437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400411x
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