Genetic and structural validation of Aspergillus fumigatus UDP-N-acetylglucosamine pyrophosphorylase as an antifungal target

The sugar nucleotide UDP-N-acetylglucosamine (UDP-GlcNAc) is an essential metabolite in both prokaryotes and eukaryotes. In fungi, it is the precursor for the synthesis of chitin, an essential component of the fungal cell wall. UDP-N-acetylglucosamine pyrophosphorylase (UAP) is the final enzyme in e...

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Main Authors: Fang, Wenxia, Du, Ting, Raimi, Olawale G, Hurtado-Guerrero, Ramon, Urbaniak, Michael D, Ibrahim, Adel F M, Ferguson, Michael A J, Jin, Cheng, Aalten, Daan M F
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley 2013
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888555/
https://ncbi.nlm.nih.gov/pubmed/23750903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12290
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