β-Arrestin–dependent activation of Ca(2+)/calmodulin kinase II after β(1)–adrenergic receptor stimulation

Por Mangmool, Supachoke, Shukla, Arun K., Rockman, Howard A.
Publicado em 2010

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

Por Shukla, Arun K., Xiao, Kunhong, Lefkowitz, Robert J.
Publicado em 2011

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

Por Reiter, Eric, Ahn, Seungkirl, Shukla, Arun K., Lefkowitz, Robert J.
Publicado em 2011

Core engagement with β-arrestin is dispensable for agonist-induced vasopressin receptor endocytosis and ERK activation

Por Kumari, Punita, Srivastava, Ashish, Ghosh, Eshan, Ranjan, Ravi, Dogra, Shalini, Yadav, Prem N., Shukla, Arun K.
Publicado no Mol Biol Cell (2017)

Arresting a Transient Receptor Potential (TRP) Channel: β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4

Por Shukla, Arun K., Kim, Jihee, Ahn, Seungkirl, Xiao, Kunhong, Shenoy, Sudha K., Liedtke, Wolfgang, Lefkowitz, Robert J.
Publicado em 2010

Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors

Por Shukla, Arun K., Violin, Jonathan D., Whalen, Erin J., Gesty-Palmer, Diane, Shenoy, Sudha K., Lefkowitz, Robert J.
Publicado em 2008

UBIQUITINATION OF β-ARRESTIN LINKS 7-TRANSMEMBRANE RECEPTOR ENDOCYTOSIS AND ERK ACTIVATION

Por Shenoy, Sudha K., Barak, Larry S., Xiao, Kunhong, Ahn, Seungkirl, Berthouze, Magali, Shukla, Arun K., Luttrell, Louis M., Lefkowitz, Robert J.
Publicado em 2007

Multiple ligand-specific conformations of the β(2)-adrenergic receptor

Por Kahsai, Alem W, Xiao, Kunhong, Rajagopal, Sudarshan, Ahn, Seungkirl, Shukla, Arun K, Sun, Jinpeng, Oas, Terrence G, Lefkowitz, Robert J
Publicado em 2011

Functional specialization of β-arrestin interactions revealed by proteomic analysis

Por Xiao, Kunhong, McClatchy, Daniel B., Shukla, Arun K., Zhao, Yang, Chen, Minyong, Shenoy, Sudha K., Yates, John R., Lefkowitz, Robert J.
Publicado em 2007

β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

Por Shenoy, Sudha K., Modi, Aalok S., Shukla, Arun K., Xiao, Kunhong, Berthouze, Magali, Ahn, Seungkirl, Wilkinson, Keith D., Miller, William E., Lefkowitz, Robert J.
Publicado em 2009

Functional competence of a partially engaged GPCR–β-arrestin complex

Por Kumari, Punita, Srivastava, Ashish, Banerjee, Ramanuj, Ghosh, Eshan, Gupta, Pragya, Ranjan, Ravi, Chen, Xin, Gupta, Bhagyashri, Gupta, Charu, Jaiman, Deepika, Shukla, Arun K.
Publicado no Nat Commun (2016)

β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice

Por Walters, Robert W., Shukla, Arun K., Kovacs, Jeffrey J., Violin, Jonathan D., DeWire, Scott M., Lam, Christopher M., Chen, J. Ruthie, Muehlbauer, Michael J., Whalen, Erin J., Lefkowitz, Robert J.
Publicado em 2009

Distinct Phosphorylation Sites on the β(2)-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of β-Arrestin

Por Nobles, Kelly N., Xiao, Kunhong, Ahn, Seungkirl, Shukla, Arun K., Lam, Christopher M., Rajagopal, Sudarshan, Strachan, Ryan T., Huang, Teng-Yi, Bressler, Erin A., Hara, Makoto R., Shenoy, Sudha K., Gygi, Steven P., Lefkowitz, Robert J.
Publicado em 2011

Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)

Por Xiao, Kunhong, Sun, Jinpeng, Kim, Jihee, Rajagopal, Sudarshan, Zhai, Bo, Villén, Judit, Haas, Wilhelm, Kovacs, Jeffrey J., Shukla, Arun K., Hara, Makoto R., Hernandez, Marylens, Lachmann, Alexander, Zhao, Shan, Lin, Yuan, Cheng, Yishan, Mizuno, Kensaku, Ma'ayan, Avi, Gygi, Steven P., Lefkowitz, Robert J.
Publicado em 2010

Structure of active β-arrestin1 bound to a G protein-coupled receptor phosphopeptide

Por Shukla, Arun K., Manglik, Aashish, Kruse, Andrew C., Xiao, Kunhong, Reis, Rosana I., Tseng, Wei-Chou, Staus, Dean P., Hilger, Daniel, Uysal, Serdar, Huang, Li-Yin, Paduch, Marcin, Tripathi-Shukla, Prachi, Koide, Akiko, Koide, Shohei, Weis, William I., Kossiakoff, Anthony A., Kobilka, Brian K., Lefkowitz, Robert J.
Publicado em 2013

Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor

Por Aristotelous, Tonia, Ahn, Seungkirl, Shukla, Arun K., Gawron, Sylwia, Sassano, Maria F., Kahsai, Alem W., Wingler, Laura M., Zhu, Xiao, Tripathi-Shukla, Prachi, Huang, Xi-Ping, Riley, Jennifer, Besnard, Jérémy, Read, Kevin D., Roth, Bryan L., Gilbert, Ian H., Hopkins, Andrew L., Lefkowitz, Robert J., Navratilova, Iva
Publicado em 2013

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

Por Cahill, Thomas J., Thomsen, Alex R. B., Tarrasch, Jeffrey T., Plouffe, Bianca, Nguyen, Anthony H., Yang, Fan, Huang, Li-Yin, Kahsai, Alem W., Bassoni, Daniel L., Gavino, Bryant J., Lamerdin, Jane E., Triest, Sarah, Shukla, Arun K., Berger, Benjamin, Little, John, Antar, Albert, Blanc, Adi, Qu, Chang-Xiu, Chen, Xin, Kawakami, Kouki, Inoue, Asuka, Aoki, Junken, Steyaert, Jan, Sun, Jin-Peng, Bouvier, Michel, Skiniotis, Georgios, Lefkowitz, Robert J.
Publicado no Proc Natl Acad Sci U S A (2017)

Visualization of arrestin recruitment by a G Protein-Coupled Receptor

Por Shukla, Arun K., Westfield, Gerwin H., Xiao, Kunhong, Reis, Rosana I., Huang, Li-Yin, Tripathi-Shukla, Prachi, Qian, Jiang, Li, Sheng, Blanc, Adi, Oleskie, Austin N., Dosey, Anne M., Su, Min, Liang, Cui-Rong, Gu, Ling-Ling, Shan, Jin-Ming, Chen, Xin, Hanna, Rachel, Choi, Minjung, Yao, Xiao Jie, Klink, Bjoern U., Kahsai, Alem W., Sidhu, Sachdev S., Koide, Shohei, Penczek, Pawel A., Kossiakoff, Anthony A., Jr, Virgil L. Woods, Kobilka, Brian K., Skiniotis, Georgios, Lefkowitz, Robert J.
Publicado em 2014