Arresting a Transient Receptor Potential (TRP) Channel: β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4

β-Arrestins, originally discovered to desensitize activated G protein-coupled receptors, (aka seven-transmembrane receptors, 7TMRs) also mediate 7TMR internalization and G protein-independent signaling via these receptors. More recently, several regulatory roles of β-arrestins for atypical 7TMRs and...

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Main Authors: Shukla, Arun K., Kim, Jihee, Ahn, Seungkirl, Xiao, Kunhong, Shenoy, Sudha K., Liedtke, Wolfgang, Lefkowitz, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943294/
https://ncbi.nlm.nih.gov/pubmed/20650893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.141549
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