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Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors
The concept of biased agonism has recently come to the fore with the realization that seven-transmembrane receptors (7TMRs, also known as G protein–coupled receptors, or GPCRs) activate complex signaling networks and can adopt multiple active conformations upon agonist binding. As a consequence, the...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3628752/ https://ncbi.nlm.nih.gov/pubmed/21942629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev.pharmtox.010909.105800 |
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