Visualization of arrestin recruitment by a G Protein-Coupled Receptor

G Protein Coupled Receptors (GPCRs) are critically regulated by β-arrestins (βarrs), which not only desensitize G protein signaling but also initiate a G protein independent wave of signaling(1-5). A recent surge of structural data on a number of GPCRs, including the β(2) adrenergic receptor (β(2)AR...

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Detalhes bibliográficos
Main Authors: Shukla, Arun K., Westfield, Gerwin H., Xiao, Kunhong, Reis, Rosana I., Huang, Li-Yin, Tripathi-Shukla, Prachi, Qian, Jiang, Li, Sheng, Blanc, Adi, Oleskie, Austin N., Dosey, Anne M., Su, Min, Liang, Cui-Rong, Gu, Ling-Ling, Shan, Jin-Ming, Chen, Xin, Hanna, Rachel, Choi, Minjung, Yao, Xiao Jie, Klink, Bjoern U., Kahsai, Alem W., Sidhu, Sachdev S., Koide, Shohei, Penczek, Pawel A., Kossiakoff, Anthony A., Jr, Virgil L. Woods, Kobilka, Brian K., Skiniotis, Georgios, Lefkowitz, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134437/
https://ncbi.nlm.nih.gov/pubmed/25043026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13430
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