Structure of active β-arrestin1 bound to a G protein-coupled receptor phosphopeptide

The functions of G-protein coupled receptors (GPCRs) are primarily mediated and modulated by three families of proteins: the heterotrimeric G proteins, the G-protein coupled receptor kinases (GRKs), and the arrestins(1). G proteins mediate activation of second messenger-generating enzymes and other...

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Hlavní autoři: Shukla, Arun K., Manglik, Aashish, Kruse, Andrew C., Xiao, Kunhong, Reis, Rosana I., Tseng, Wei-Chou, Staus, Dean P., Hilger, Daniel, Uysal, Serdar, Huang, Li-Yin, Paduch, Marcin, Tripathi-Shukla, Prachi, Koide, Akiko, Koide, Shohei, Weis, William I., Kossiakoff, Anthony A., Kobilka, Brian K., Lefkowitz, Robert J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654799/
https://ncbi.nlm.nih.gov/pubmed/23604254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12120
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