Enhancement of mDia2 activity by Rho-kinase-dependent phosphorylation of the diaphanous autoregulatory domain

por Staus, Dean P., Taylor, Joan M., Mack, Christopher P.
Publicado en Biochem J (2011)

Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes

por Pakharukova, Natalia, Masoudi, Ali, Pani, Biswaranjan, Staus, Dean P., Lefkowitz, Robert J.
Publicado en J Biol Chem (2021)

Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G-protein–coupled receptors

por Staus, Dean P., Wingler, Laura M., Pichugin, Dmitry, Prosser, Robert Scott, Lefkowitz, Robert J.
Publicado en J Biol Chem (2019)

S1P Receptor 2 Signals Through the RGS-RhoGEF, LARG, To Promote Smooth Muscle Cell Differentiation

por Medlin, Matt D., Staus, Dean P., Dubash, Adi D., Taylor, Joan M., Mack, Christopher P.
Publicado 2010

Formin Homology Domain-Containing Protein 1 (FHOD1) Regulates Smooth Muscle Cell Phenotype

por Staus, Dean P., Blaker, Alicia L., Medlin, Matt D., Taylor, Joan M., Mack, Christopher P.
Publicado 2010

Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody

por Wingler, Laura M., McMahon, Conor, Staus, Dean P., Lefkowitz, Robert J., Kruse, Andrew C.
Publicado en Cell (2019)

Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling

por Staus, Dean P., Wingler, Laura M., Choi, Minjung, Pani, Biswaranjan, Manglik, Aashish, Kruse, Andrew C., Lefkowitz, Robert J.
Publicado en Proc Natl Acad Sci U S A (2018)

Nuclear RhoA signaling regulates MRTF-dependent SMC-specific transcription

por Staus, Dean P., Weise-Cross, Laura, Mangum, Kevin D., Medlin, Matt D., Mangiante, Lee, Taylor, Joan M., Mack, Christopher P.
Publicado 2014

Multidimensional tracking of GPCR signaling via peroxidase-catalyzed proximity labeling

por Paek, Jaeho, Kalocsay, Marian, Staus, Dean P., Wingler, Laura, Pascolutti, Roberta, Paulo, Joao A., Gygi, Steven P., Kruse, Andrew C.
Publicado en Cell (2017)

Gα(i) is required for carvedilol-induced β(1) adrenergic receptor β-arrestin biased signaling

por Wang, Jialu, Hanada, Kenji, Staus, Dean P., Makara, Michael A., Dahal, Giri Raj, Chen, Qiang, Ahles, Andrea, Engelhardt, Stefan, Rockman, Howard A.
Publicado en Nat Commun (2017)

Regulation of β(2)-Adrenergic Receptor Function by Conformationally Selective Single-Domain Intrabodies

por Staus, Dean P., Wingler, Laura M., Strachan, Ryan T., Rasmussen, Soren G. F., Pardon, Els, Ahn, Seungkirl, Steyaert, Jan, Kobilka, Brian K., Lefkowitz, Robert J.
Publicado 2014

Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc

por Staus, Dean P., Hu, Hongli, Robertson, Michael J., Kleinhenz, Alissa L. W., Wingler, Laura M., Capel, William D., Latorraca, Naomi R., Lefkowitz, Robert J., Skiniotis, Georgios
Publicado en Nature (2020)

Angiotensin analogs with divergent bias stabilize distinct receptor conformations

por Wingler, Laura M., Elgeti, Matthias, Hilger, Daniel, Latorraca, Naomi R., Lerch, Michael T., Staus, Dean P., Dror, Ron O., Kobilka, Brian K., Hubbell, Wayne L., Lefkowitz, Robert J.
Publicado en Cell (2019)

Synthetic nanobodies as angiotensin receptor blockers

por McMahon, Conor, Staus, Dean P., Wingler, Laura M., Wang, Jialu, Skiba, Meredith A., Elgeti, Matthias, Hubbell, Wayne L., Rockman, Howard A., Kruse, Andrew C., Lefkowitz, Robert J.
Publicado en Proc Natl Acad Sci U S A (2020)

Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR

por Wingler, Laura M., Skiba, Meredith A., McMahon, Conor, Staus, Dean P., Kleinhenz, Alissa L. W., Suomivuori, Carl-Mikael, Latorraca, Naomi R., Dror, Ron O., Lefkowitz, Robert J., Kruse, Andrew C.
Publicado en Science (2020)

Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor

por Suomivuori, Carl-Mikael, Latorraca, Naomi R., Wingler, Laura M., Eismann, Stephan, King, Matthew C., Kleinhenz, Alissa L. W., Skiba, Meredith A., Staus, Dean P., Kruse, Andrew C., Lefkowitz, Robert J., Dror, Ron O.
Publicado en Science (2020)

Mechanism of β(2)AR regulation by an intracellular positive allosteric modulator

por Liu, Xiangyu, Masoudi, Ali, Kahsai, Alem W., Huang, Li-Yin, Pani, Biswaranjan, Staus, Dean P., Shim, Paul J., Hirata, Kunio, Simhal, Rishabh K., Schwalb, Allison M., Rambarat, Paula K., Ahn, Seungkirl, Lefkowitz, Robert J., Kobilka, Brian
Publicado en Science (2019)

Noncanonical scaffolding of G(αi) and β-arrestin by G protein–coupled receptors

por Smith, Jeffrey S., Pack, Thomas F., Inoue, Asuka, Lee, Claudia, Zheng, Kevin, Choi, Issac, Eiger, Dylan S., Warman, Anmol, Xiong, Xinyu, Ma, Zhiyuan, Viswanathan, Gayathri, Levitan, Ian M., Rochelle, Lauren K., Staus, Dean P., Snyder, Joshua C., Kahsai, Alem W., Caron, Marc G., Rajagopal, Sudarshan
Publicado en Science (2021)

Allosteric Nanobodies Reveal the Dynamic Range and Diverse Mechanisms of GPCR Activation

por Staus, Dean P, Strachan, Ryan T, Manglik, Aashish, Pani, Biswaranjan, Kahsai, Alem W, Kim, Tae Hun, Wingler, Laura M, Ahn, Seungkirl, Chatterjee, Arnab, Masoudi, Ali, Kruse, Andrew C, Pardon, Els, Steyaert, Jan, Weis, William I, Prosser, R. Scott, Kobilka, Brian K, Costa, Tommaso, Lefkowitz, Robert J
Publicado en Nature (2016)

Structure of active β-arrestin1 bound to a G protein-coupled receptor phosphopeptide

por Shukla, Arun K., Manglik, Aashish, Kruse, Andrew C., Xiao, Kunhong, Reis, Rosana I., Tseng, Wei-Chou, Staus, Dean P., Hilger, Daniel, Uysal, Serdar, Huang, Li-Yin, Paduch, Marcin, Tripathi-Shukla, Prachi, Koide, Akiko, Koide, Shohei, Weis, William I., Kossiakoff, Anthony A., Kobilka, Brian K., Lefkowitz, Robert J.
Publicado 2013