Synthetic nanobodies as angiotensin receptor blockers

There is considerable interest in developing antibodies as functional modulators of G protein-coupled receptor (GPCR) signaling for both therapeutic and research applications. However, there are few antibody ligands targeting GPCRs outside of the chemokine receptor group. GPCRs are challenging targe...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: McMahon, Conor, Staus, Dean P., Wingler, Laura M., Wang, Jialu, Skiba, Meredith A., Elgeti, Matthias, Hubbell, Wayne L., Rockman, Howard A., Kruse, Andrew C., Lefkowitz, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7443875/
https://ncbi.nlm.nih.gov/pubmed/32753386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009029117
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