Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development

Por Kruse, Andrew C., Hu, Jianxin, Kobilka, Brian K., Wess, Jürgen
Publicado em 2014

Applications of molecular replacement to G protein-coupled receptors

Por Kruse, Andrew C., Manglik, Aashish, Kobilka, Brian K., Weis, William I.
Publicado em 2013

Novel Insights Into M(3) Muscarinic Acetylcholine Receptor Physiology and Structure

Por Kruse, Andrew C., Li, Jianhua, Hu, Jianxin, Kobilka, Brian K., Wess, Jürgen
Publicado em 2013

Negative selection and peptide chemistry determine the size of naïve foreign peptide-MHCII-specific CD4(+) T cell populations

Por Chu, H. Hamlet, Moon, James J., Kruse, Andrew C., Pepper, Marion, Jenkins, Marc K.
Publicado em 2010

Reduced ability of C-type natriuretic peptide (CNP) to activate natriuretic peptide receptor B (NPR-B) causes dwarfism in lbab(−/−) mice

Por Yoder, Andrea R., Kruse, Andrew C., Earhart, Cathleen A., Ohlendorf, Douglas H., Potter, Lincoln R.
Publicado no Peptides (2008)

Structure of a mutant β toxin from Staphylococcus aureus reveals domain swapping and conformational flexibility

Por Kruse, Andrew C., Huseby, Medora J., Shi, Ke, Digre, Jeff, Ohlendorf, Douglas H., Earhart, Cathleen A.
Publicado em 2011

Non-classical amine recognition evolved in a large clade of olfactory receptors

Por Li, Qian, Tachie-Baffour, Yaw, Liu, Zhikai, Baldwin, Maude W, Kruse, Andrew C, Liberles, Stephen D
Publicado no eLife (2015)

X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal

Por Hellberg, Kristina, Grimsrud, Paul A, Kruse, Andrew C, Banaszak, Leonard J, Ohlendorf, Douglas H, Bernlohr, David A
Publicado em 2010

Structure and dynamics of PD-L1 and an ultra high-affinity PD-1 receptor mutant

Por Pascolutti, Roberta, Sun, Xianqiang, Kao, Joseph, Maute, Roy, Ring, Aaron M., Bowman, Gregory R., Kruse, Andrew C.
Publicado no Structure (2016)

Covalent agonists for studying G protein-coupled receptor activation

Por Weichert, Dietmar, Kruse, Andrew C., Manglik, Aashish, Hiller, Christine, Zhang, Cheng, Hübner, Harald, Kobilka, Brian K., Gmeiner, Peter
Publicado em 2014

Structure of the δ-opioid receptor bound to naltrindole

Por Granier, Sébastien, Manglik, Aashish, Kruse, Andrew C., Kobilka, Tong Sun, Thian, Foon Sun, Weis, William I., Kobilka, Brian K.
Publicado em 2012

Adrenaline-activated structure of the β(2)-adrenoceptor stabilized by an engineered nanobody

Por Ring, Aaron M., Manglik, Aashish, Kruse, Andrew C., Enos, Michael D., Weis, William I., Garcia, K. Christopher, Kobilka, Brian K.
Publicado em 2013

Crystal structure of a full-length human tetraspanin reveals a cholesterol-binding pocket

Por Zimmerman, Brandon, Kelly, Brendan, McMillan, Brian J., Seegar, Tom C.M., Dror, Ron O., Kruse, Andrew C., Blacklow, Stephen C.
Publicado no Cell (2016)

Muscarinic Receptors as Model Targets and Antitargets for Structure-Based Ligand Discovery

Por Kruse, Andrew C., Weiss, Dahlia R., Rossi, Mario, Hu, Jianxin, Hu, Kelly, Eitel, Katrin, Gmeiner, Peter, Wess, Jürgen, Kobilka, Brian K., Shoichet, Brian K.
Publicado em 2013

Structure of the human M(2) muscarinic acetylcholine receptor bound to an antagonist

Por Haga, Kazuko, Kruse, Andrew C., Asada, Hidetsugu, Yurugi-Kobayashi, Takami, Shiroishi, Mitsunori, Zhang, Cheng, Weis, William I., Okada, Tetsuji, Kobilka, Brian K., Haga, Tatsuya, Kobayashi, Takuya
Publicado em 2012

Structural Basis of Specificity and Cross-Reactivity in T Cell Receptors Specific for Cytochrome c–I-E(k)

Por Newell, Evan W., Ely, Lauren K., Kruse, Andrew C., Reay, Philip A., Rodriguez, Stephanie N., Lin, Aaron E., Kuhns, Michael S., Garcia, K. Christopher, Davis, Mark M.
Publicado em 2011

Crystal structure of the μ-opioid receptor bound to a morphinan antagonist

Por Manglik, Aashish, Kruse, Andrew C., Kobilka, Tong Sun, Thian, Foon Sun, Mathiesen, Jesper M., Sunahara, Roger K., Pardo, Leonardo, Weis, William I., Kobilka, Brian K., Granier, Sébastien
Publicado em 2012

SEDS proteins are a widespread family of bacterial cell wall polymerases

Por Meeske, Alexander J., Riley, Eammon P., Robins, William P., Uehara, Tsuyoshi, Mekelanos, John J., Kahne, Daniel, Walker, Suzanne, Kruse, Andrew C., Bernhardt, Thomas G., Rudner, David Z.
Publicado no Nature (2016)

Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins

Por Hertzel, Ann V., Hellberg, Kristina, Reynolds, Joseph M., Kruse, Andrew C., Juhlmann, Brittany E., Smith, Anne J., Sanders, Mark A., Ohlendorf, Douglas H., Suttles, Jill, Bernlohr, David A.
Publicado em 2009

Beta toxin catalyzes formation of nucleoprotein matrix in staphylococcal biofilms

Por Huseby, Medora J., Kruse, Andrew C., Digre, Jeff, Kohler, Petra L., Vocke, Jillian A., Mann, Ethan E., Bayles, Kenneth W., Bohach, Gregory A., Schlievert, Patrick M., Ohlendorf, Douglas H., Earhart, Cathleen A.
Publicado em 2010